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ภาวะตาบอดสีน้ำเงิน-เหลืองที่พบได้น้อย เกิดจากการขาดเซลล์รับสีน้ำเงิน ทำให้แยกแยะสีน้ำเงินและสีเหลืองได้ยาก
Tritanopia affects fewer than 0.01% of the population and is equally common in males and females (unlike red-green deficiencies, which are X-linked). People with tritanopia lack S-cone (short wavelength, blue-sensitive) photoreceptors, causing blue to appear greenish and yellow to appear pinkish. Purple and blue become difficult to distinguish, as do yellow and white. While rare, tritanopia can be acquired through aging, retinal disease, or medication side effects. Designing for tritanopia means avoiding blue-yellow as the sole color distinction and ensuring sufficient luminance contrast.